Bortezomib injection is used to deal with multiple myeloma (blood plasma cell cancer) in people with or with out a former background of procedure, and mantle mobile lymphoma.
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fedratinib will boost the degree or influence of bortezomib by influencing hepatic enzyme CYP2C19 metabolism. Use Caution/Keep an eye on. Adjust dose of medications that are CYP2C19 substrates as required.
cenobamate will improve the level or outcome of bortezomib by affecting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Check Carefully. Take into consideration a dose reduction of CYP2C19 substrates, as clinically suitable, when utilised concomitantly with cenobamate.
Assessment Panobinostat: A histone deacetylase inhibitor for the cure of relapsed or refractory several myeloma.
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bortezomib increases amounts of lomitapide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. Lomitapide dose should not exceed 30 mg/day.
voriconazole will improve the degree or result of bortezomib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
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bortezomib improves amounts of eliglustat by affecting hepatic enzyme CYP2D6 metabolism. Contraindicated. If coadministered with robust or reasonable CYP2D6 inhibitors, lower eliglustat dose from eighty four mg BID to 84 mg the moment each day in considerable and intermediate metabolizers; eliglustat is contraindiated if solid or reasonable CYP2D6 inhibitors are specified concomitantly with sturdy or reasonable CYP3A inhibitors.
cyclophosphamide will increase the degree or influence of bortezomib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unfamiliar.
rifampin will reduce the extent or outcome of bortezomib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
etravirine will decrease the level or result of bortezomib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
crizotinib will increase amounts of bortezomib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. Dose reduction can be required for coadministered drugs that happen to be predominantly metabolized by CYP3A.